Hyptis pectinata gel prevents alveolar bone resorption in experimental periodontitis in rats
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چکیده
منابع مشابه
Disodium chlodronate prevents bone resorption in experimental periodontitis in rats.
BACKGROUND Periodontitis is a chronic disease characterized by alveolar bone loss and inflammatory changes. We studied the effect of disodium chlodronate (CD), a bisphosphonate used in metastatic and metabolic bone disease as a bone resorbing drug, in an experimental periodontitis model (EPD) focusing on anti-resorptive and anti-inflammatory parameters. METHODS A nylon thread ligature was pla...
متن کاملEffect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats.
BACKGROUND Bisphosphonates are potent inhibitors of bone resorption and were shown to inhibit bone resorption in experimental periodontitis by unknown mechanisms. We studied the effect of the aminobisphosphonate sodium alendronate (SA) in experimental periodontitis. Wistar rats were subjected to ligature placement around the second upper left molars. METHODS Animals were treated with SA 0.01 ...
متن کاملBis-Enoxacin Blocks Rat Alveolar Bone Resorption from Experimental Periodontitis
Periodontal diseases are multifactorial, caused by polymicrobial subgingival pathogens, including Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. Chronic periodontal infection results in inflammation, destruction of connective tissues, periodontal ligament, and alveolar bone resorption, and ultimately tooth loss. Enoxacin and a bisphosphonate derivative of enoxacin (bis...
متن کاملA novel inhibitor of vacuolar ATPase, FR202126, prevents alveolar bone destruction in experimental periodontitis in rats.
An acidic microenvironment formed by vacuolar ATPase (V-ATPase) expressed in plasma membranes of osteoclasts is thought to be indispensable for bone resorption. This study examined the efficacy of a novel V-ATPase inhibitor, FR202126, in reducing alveolar bone loss caused by experimental periodontitis in rats. FR202126 inhibited H+ transport in plasma membrane vesicles of murine osteoclasts, wh...
متن کاملThe effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats
Objectives The frst cause of tooth loss in developed countries is periodontitis and mostly occurs in people over 40 years old.Atorvastatin is a statin drug class, which has a revolutionary impact on the treatment of high cholesterol and also stimulates bone morphogenic protein which has osteogenic potential. The aim of this study was to evaluate the effect of local and systemic Atorvastatin in...
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ژورنال
عنوان ژورنال: Revista Brasileira de Farmacognosia
سال: 2015
ISSN: 0102-695X
DOI: 10.1016/j.bjp.2014.12.002